Eukaryotic DNA polymerase ζ
نویسندگان
چکیده
منابع مشابه
Eukaryotic DNA polymerase ζ.
This review focuses on eukaryotic DNA polymerase ζ (Pol ζ), the enzyme responsible for the bulk of mutagenesis in eukaryotic cells in response to DNA damage. Pol ζ is also responsible for a large portion of mutagenesis during normal cell growth, in response to spontaneous damage or to certain DNA structures and other blocks that stall DNA replication forks. Novel insights in mutagenesis have be...
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During replication in yeast, the three B family DNA replicases frequently incorporate ribonucleotides (rNMPs) into DNA, and their presence in the nuclear genome can affect genome stability. This prompted us to examine ribonucleotide incorporation by the fourth B family member, Pol ζ, the enzyme responsible for the majority of damage-induced mutagenesis in eukaryotes. We first show that Pol ζ in...
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seen in this study for verbs, in the processing of time and temporal structure [10]. While Shapiro et al. [3] are admirably restrained in their interpretations, they outline how their results suggest there is some relationship between grammatical class and semantic representations. This is a far from trivial issue: from a classic psycho-linguistic perspective, semantic and syntactic representat...
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Translesion DNA synthesis is an important branch of the DNA damage tolerance pathway that assures genomic integrity of living organisms. The mechanisms of DNA polymerase (Pol) switches during lesion bypass are not known. Here, we show that the C-terminal domain of the Pol ζ catalytic subunit interacts with accessory subunits of replicative DNA Pol δ. We also show that, unlike other members of t...
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The replicative DNA polymerase Polδ consists of a catalytic subunit POLD1/p125 and three regulatory subunits POLD2/p50, POLD3/p66 and POLD4/p12. The ortholog of POLD3 in Saccharomyces cerevisiae, Pol32, is required for a significant proportion of spontaneous and UV-induced mutagenesis through its additional role in translesion synthesis (TLS) as a subunit of DNA polymerase ζ. Remarkably, chicke...
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2015
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2015.02.012